Long-term Survival of Lethally Irradiated Dogs given Homografts of Bone Marrow.

D OGS given lethal total-body exposure to radiation, in the range below that causing death from intestinal damage, can survive if suitable supportive treatment is given and if a successful transplant of marrow is made.14 The duration of survival is varied, depending primarily upon success in overcoming delayed secondary syndromes relating to the graft of foreign marrow. The severity of the syndromes depends upon the degree of foreignness of the transplant and the degree of control of its reaction with antimetabolites.5 \Then all goes well, survival rates of up to 50 per cent can be obtained in the dog.5’” The general well-being of these long-term survivors is a matter of clinical interest and a subject of the following communication.